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KMID : 0624620180510010033
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BMB Reports
2018 Volume.51 No. 1 p.33 ~ p.38
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HCBP6 upregulates human SREBP1c expression by binding to C/EBPβ-binding site in the SREBP1c promoter
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Yang Xueliang
Han Ming
Liu Shunai
Yuan Xiaoxue
Liu Xiaojing
Feng Shenghu
Zhou Li
Li Yaru
Lu Hongping
Cheng Jun
Lin Shumei
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Abstract
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Sterol regulatory element-binding protein-1c (SREBP1c) plays an important role in triglyceride (TG) homeostasis. Although our previous study showed that hepatitis C virus core-binding protein 6 (HCBP6) regulates SREBP1c expression to maintain intracellular TG homeostasis, the mechanism underlying this regulation is unclear. In the present study, we found that HCBP6 increased intracellular TG levels by upregulating SREBP1c expression. HCBP6 increased SREBP1c transcription by directly binding to the SREBP1c promoter (at the ?139- to +359-bp region). Moreover, we observed that HCBP6 interacted with C/EBPβ-binding site in the SREBP1c promoter both in vitro and in vivo. These results indicate that HCBP6 upregulates human SREBP1c expression by binding to the C/EBPβ-binding site in the SREBP1c promoter.
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KEYWORD
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C/EBPβ, HCBP6, SREBP1c, Transcription factor, Triglyceride homeostasis
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